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DALK rejection following vaccination against SARS-CoV-2: 2 case reports
1Swarup Eye Centre, Hyderabad, Telangana, India.
European Journal of Ophthalmology
|March 6, 2023
Summary
Deep anterior lamellar keratoplasty (DALK) rejection is a rare complication that can occur after SARS-CoV-2 vaccination. Prompt corticosteroid treatment led to recovery in two reported cases.
Area of Science:
- Ophthalmology
- Immunology
- Vaccinology
Background:
- Deep anterior lamellar keratoplasty (DALK) is a surgical procedure for corneal diseases.
- SARS-CoV-2 vaccination has become widespread globally.
- Immunologic complications following vaccination are a growing area of research.
Purpose of the Study:
- To document two instances of DALK rejection.
- To investigate the potential link between SARS-CoV-2 vaccination and DALK rejection.
Main Methods:
- Case report of two patients with a history of DALK.
- Observation of rejection episodes following SARS-CoV-2 vaccination (COVAXIN and COVISHIELD).
- Treatment with topical corticosteroids and monitoring of outcomes.
Main Results:
- Two patients experienced immunologic rejection post-vaccination.
- Both patients responded well to topical corticosteroid therapy.
- Complete resolution of corneal edema and improved visual acuity were observed in both cases.
Conclusions:
- SARS-CoV-2 vaccination may rarely trigger DALK rejection.
- Further research is needed to establish clear guidelines for risk assessment, monitoring, and treatment.
- This highlights a potential, albeit rare, adverse event following immunization.
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