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Graft rejection in component keratoplasty.

Rashmi Deshmukh1, Somasheila I Murthy1, Christopher J Rapuano2

  • 1L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

Indian Journal of Ophthalmology
|March 6, 2023
PubMed
Summary

Failed corneal grafts, often due to endothelial rejection, are common. Component keratoplasty, replacing only diseased layers, improves outcomes but can still experience rejection, requiring specific diagnosis and treatment strategies.

Keywords:
Component keratoplastycorneal transplantationlamellar keratoplastyrejection

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Transplantation Immunology

Background:

  • Failed corneal grafts are a leading cause of repeat keratoplasty.
  • Endothelial rejection remains the primary factor in graft failure.
  • Component keratoplasty offers an alternative to traditional full-thickness procedures.

Purpose of the Study:

  • To review the current understanding of graft rejection in component keratoplasty.
  • To summarize the diverse presentations and diagnostic approaches.
  • To outline management strategies for component graft rejection.

Main Methods:

  • Literature review of component keratoplasty and graft rejection.
  • Analysis of case reports and series detailing rejection episodes.
  • Synthesis of diagnostic criteria and treatment protocols.

Main Results:

  • Component keratoplasty significantly reduces endothelial rejection compared to penetrating keratoplasty.
  • Rejection in component grafts presents uniquely and requires tailored treatment.
  • Early diagnosis and appropriate management are crucial for graft survival.

Conclusions:

  • While component keratoplasty improves graft survival, rejection remains a concern.
  • Understanding the specific presentations and management of component graft rejection is vital.
  • Further research is needed to optimize prevention and treatment strategies.