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Updated: Aug 8, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching
Kevin Swierkosz-Lenart1, Joao Flores Alves Dos Santos2, Julien Elowe3,4
1Department of Psychiatry, Service Universitaire de Psychiatrie de l'Age Avancé (SUPAA), Centre Hospitalier Universitaire Vaudois, Prilly, Switzerland.
Abstract:
Even though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30-40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacological approaches, when properly applied, prove ineffective in about 10% of cases. The use of neuromodulation techniques, especially Deep Brain Stimulation, is highly promising for these clinical pictures and knowledge in this domain is constantly evolving. The aim of this paper is to provide a summary of the current knowledge about OCD treatment, while also discussing the more recent proposals for defining resistance.
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