Related Experiment Video
Updated: Aug 8, 2025

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Portal vein thrombosis on unenhanced MRI: a case series
1Department of Radiology, Tan Tock Seng Hospital, Singapore, Singapore.
Abstract:
Portal vein thrombosis (PVT) is usually diagnosed on contrast-enhanced CT, MRI or Doppler ultrasound. However, for patients with contraindications to intravenous contrast, its diagnosis is challenging. In these patients, PVT can be detected on unenhanced MRI using T2, T1 and diffusion-weighted imaging. These sequences may also help differentiate between bland PVT, portal pyemia and tumour thrombus. This case series aims to highlight the various appearances of PVT on unenhanced MRI.
Insights
Diagnosing portal vein thrombosis (PVT) without contrast is challenging. Unenhanced MRI sequences effectively detect PVT and help differentiate thrombus types in patients with contrast contraindications.
Area of Science:
- Radiology
- Medical Imaging
- Gastroenterology
Background:
- Portal vein thrombosis (PVT) is a common condition often diagnosed using contrast-enhanced imaging modalities.
- Intravenous contrast agents carry risks, including allergic reactions and nephrotoxicity, limiting their use in certain patient populations.
- Accurate diagnosis of PVT is crucial for appropriate management and preventing complications.
Observation:
- Unenhanced magnetic resonance imaging (MRI) techniques, including T2, T1, and diffusion-weighted imaging (DWI), can visualize PVT.
- These MRI sequences offer insights into the characteristics of the thrombus.
- The study highlights the diverse appearances of PVT on unenhanced MRI.
Findings:
- Unenhanced MRI is a valuable tool for detecting PVT in contrast-allergic patients.
- Specific MRI sequences aid in differentiating bland PVT from other conditions like portal pyemia and tumor thrombus.
- The case series demonstrates the utility of various unenhanced MRI sequences in characterizing PVT.
Implications:
- This approach expands diagnostic capabilities for PVT in a specific patient population.
- Unenhanced MRI provides a safe and effective alternative when contrast administration is not feasible.
- Improved diagnostic accuracy for PVT in contrast-contraindicated patients can lead to timely interventions and better outcomes.
Related Concept Videos
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis I: Introduction
Venous Thrombosis III: Interprofessional Care
Imaging Studies VII: Vascular Imaging
Venous Thrombosis IV: Nursing Management
Varicose Veins II: Diagnostic Studies and Interprofessional Care

