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Updated: Aug 8, 2025

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Primary vaginal signet ring cell carcinoma

Xiao-Shan Huang1, Shu-Feng Fan1, Jian-Xia Xu1

  • 1Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

BJR Case Reports
|March 6, 2023
PubMed
Summary

Primary vaginal cancer is rare. This report details a unique case of primary signet ring cell carcinoma of the vagina, a subtype previously undocumented in medical literature.

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The vaginal canal is a tubular structure averaging about 10 cm in length that acts as the entryway to the female reproductive system and the passageway for menstrual flow and childbirth. The interior walls of the vagina exhibit concentric folds called rugae and are topped by an area known as the fornix, which connects with the protruding cervical portion of the uterus. This canal is comprised of an external fibrous layer, a muscular middle layer, and an inner lining with mucosal rugae, which...
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