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Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Related Experiment Video

Updated: Aug 8, 2025

Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Published on: June 9, 2023

Fat necrosis: A consultant's conundrum.

Jinita Majithia¹, Purvi Haria¹, Palak Popat¹

¹Radiology Department, Tata Memorial Hospital, Mumbai, India.

Frontiers in Oncology

|March 6, 2023

Summary

This summary is machine-generated.

Fat necrosis of the breast is a benign condition that can mimic breast cancer on imaging. This review details its varied appearances across imaging modalities to aid diagnosis and prevent unnecessary interventions.

Keywords:

breast imaging fat necrosis mammography radiology ultrasonography

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Area of Science:

Radiology
Pathology
Oncology

Background:

Fat necrosis of the breast is a benign inflammatory condition of adipose tissue.
It frequently mimics malignant breast tumors, presenting a diagnostic challenge.
Imaging findings can be diverse and sometimes misleading, particularly in post-treatment cases.

Purpose of the Study:

To provide a comprehensive literature review of fat necrosis imaging appearances.
To highlight the diagnostic challenges posed by fat necrosis.
To propose a systematic diagnostic algorithm for fat necrosis.

Main Methods:

Literature review of various imaging modalities including mammography, contrast-enhanced mammography, ultrasound, and MRI.
Analysis of imaging features associated with fat necrosis.
Synthesis of information to develop a diagnostic approach.

Main Results:

Fat necrosis exhibits a wide spectrum of imaging findings, from pathognomonic signs like oil cysts to indeterminate features.
Imaging characteristics can be misleading, necessitating careful evaluation.
Multimodality imaging is crucial for accurate diagnosis.

Conclusions:

Fat necrosis, while benign, requires careful imaging assessment due to its potential to mimic malignancy.
A systematic approach utilizing multiple imaging modalities can improve diagnostic accuracy.
This review offers a comprehensive overview and a proposed algorithm to aid radiologists in diagnosing fat necrosis.