Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas
Josephine Emole1, Odunayo Lawal2, Oleksandra Lupak3
1Stem Cell Transplantation and Cellular Therapy, Henry Ford Hospital, Detroit, MI, United States.
Objective:
To evaluate risk factors for neuropsychiatric disorders (NPD) in recipients of CART therapy.
Methods:
Patients ≥ 18 years with acute lymphoblastic leukemia (ALL), and aggressive B-cell lymphomas who received CART in 2018 were evaluated. Patients with and without NPD were compared.
Results:
NPD was diagnosed in 31.2% of patients. Compared to patients without NPD, patients with NPD were likely to be females (P = 0.035) and have ALL (P = 0.039). NPD was significantly associated with female gender (OR = 2.03) and diagnosis of ALL (OR = 2.76). No association between NPD and outcomes.
Conclusions:
Female gender and ALL were risk factors for NPD.
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