Related Experiment Video

Updated: Aug 8, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:15

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

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Incidence, Clinical Correlates, and Prognostic Impact of Dementia in Heart Failure: A Population-Based Cohort Study

Qing-Wen Ren1,2, Tiew-Hwa Katherine Teng3,4,5, Yi-Kei Tse2

  • 1Cardiology Division, Department of Medicine, The University of Hong Kong Shen Zhen Hospital, Shen Zhen, China.

JACC. Asia
|March 6, 2023
PubMed

Insights

Heart failure (HF) increases dementia risk, particularly in older women. New-onset dementia in HF patients significantly elevates mortality risk, necessitating targeted screening and prevention strategies.

Area of Science:

  • Cardiology
  • Neurology
  • Geriatrics

Background:

  • Heart failure (HF) is a growing concern, potentially linked to increased dementia risk through shared risk factors.
  • Understanding this association is crucial for comprehensive patient care and public health strategies.

Purpose of the Study:

  • To investigate the incidence, types, clinical correlates, and prognostic impact of dementia in a large, population-based cohort of patients with heart failure.
  • To identify key predictors of dementia in heart failure patients and assess its effect on all-cause mortality.

Main Methods:

  • A territory-wide database was used to identify 20,221 patients with heart failure between 1995 and 2018.
  • Multivariable Cox/competing risk regression models were employed to analyze clinical correlates and mortality associations.

Main Results:

  • 11.0% of heart failure patients developed new-onset dementia, with higher incidence in women (1,297/10,000) than men (744/10,000).
  • Key predictors included older age (≥75 years), female sex, Parkinson's disease, stroke, and hypertension.
  • Dementia was independently associated with a 4.51-fold increased risk of all-cause mortality.

Conclusions:

  • New-onset dementia affects over 10% of heart failure patients, significantly worsening prognosis.
  • Older women are at the highest risk, highlighting the need for targeted screening and preventive interventions.
Abstract

Keywords:
AD, Alzheimer’s diseaseCDARS, Clinical Data Analysis and Reporting SystemCVD, cardiovascular deathHF, heart failureICD, International Classification of DiseasesPAF, population attributable fractionsSHR, subdistribution hazard ratioVD, vascular dementiaclinical correlatesdementiaheart failuremortalitysex differ

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