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Related Experiment Video

Updated: Aug 8, 2025

Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
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Development, initial validation, and application of a visual read method for [18F]MK-6240 tau PET.

Joanna L Shuping1, Dawn C Matthews2, Katarzyna Adamczuk3

  • 1Enigma Biomedical Group Toronto Ontario Canada.

Alzheimer'S & Dementia (New York, N. Y.)
|March 6, 2023
PubMed

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Same author

Longitudinal cognitive outcomes in two progressive supranuclear palsy clinical trials.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
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Trajectories of brain structure and function in young adult carriers of genetic frontotemporal dementia variants.

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Clinical Associations of Cerebrospinal Fluid TMEM106B in Familial and Sporadic Frontotemporal Dementia.

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Development and validation of a harmonized memory score for multicenter Alzheimer's disease and related dementia research.

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The BEYONDD Pilot Study: A Decentralized Community-Engaged Research Framework for Multimodal Characterization of Neurodegenerative Risk in a Multi-Ethnic, Midlife Cohort with Subjective Cognitive or Behavioral Complaints.

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Remote, self-administered, smartphone cognitive testing in a registry-based cohort: Feasibility, reliability, and validity findings.

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Summary

A new visual read method for [18F]MK-6240 tau positron emission tomography (PET) scans is highly reproducible and clinically relevant. This method reliably classifies tau PET scans for Alzheimer's disease (AD) identification and staging.

Area of Science:

  • Neuroimaging
  • Radiopharmaceutical Development
  • Alzheimer's Disease Diagnostics

Background:

  • The [18F]MK-6240 positron emission tomography (PET) radiotracer targets neurofibrillary tangles (NFTs) in Alzheimer's disease (AD).
  • It demonstrates high specificity, sensitivity, and low background signal in the brain.
  • Clinical application requires a standardized visual assessment method for identifying and staging AD.

Purpose of the Study:

  • To develop and validate a reproducible, clinically relevant visual read method for [18F]MK-6240 PET scans.
  • To support the identification and staging of AD subjects compared to non-AD individuals and controls.

Main Methods:

  • Five expert readers initially assessed 30 mixed-diagnosis scans, providing input on assessment features and clinical relevance.
Keywords:
Alzheimer's diseaseMK‐6240[18F]MK‐6240florquinitauneurofibrillary tanglespositron emission tomographytautracervisual read

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  • A four-class visual read classification system was defined based on reader input and scan characteristics.
  • The method was validated through training two naïve readers, testing inter-rater agreement on 131 scans, and applying it to a diverse database of 1842 scans.

    • Main Results:

    • A four-class visual read method was established: no uptake, medial temporal lobe (MTL) only, MTL and neocortical uptake, or uptake outside MTL.
    • Excellent inter-rater reliability was achieved, with kappas of 1.0 for naïve readers and 0.98 for independent readers.
    • All 1842 scans in the diverse database were successfully classified, with frequencies aligning with NFT histopathology literature.

    Conclusions:

    • The developed four-class visual read method for [18F]MK-6240 tau PET is trainable, reproducible, and clinically relevant.
    • It accurately captures tau distribution patterns, including medial temporal, neocortical, and atypical patterns, supporting disease staging.
    • This method facilitates the clinical use of [18F]MK-6240 PET for Alzheimer's disease assessment.