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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Related Experiment Video

Updated: Aug 8, 2025

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
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Epigenetic reprogramming in pancreatic premalignancy and clinical implications.

Wei Zhang1,2, Tingting Jiang1,2, Keping Xie1,2

  • 1Center for Pancreatic Cancer Research, School of Medicine, The South China University of Technology, Guangzhou, China.

Frontiers in Oncology
|March 6, 2023
PubMed
Summary

Epigenetic changes drive pancreatic cancer initiation and progression. Understanding these epigenetic reprogramming events in premalignant lesions offers potential for early diagnosis and targeted therapies for pancreatic cancer.

Keywords:
detectionepigeneticspancreatic cancerpancreatic premalignancytherapy

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Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Pancreatic cancer (PC) has a low survival rate, with premalignant lesions initiating the disease.
  • Pancreatic premalignant lesions, including PanIN, IPMN, and MCN, arise from acinar-to-ductal metaplasia (ADM).
  • Epigenetic dysregulation is an early event in pancreatic tumorigenesis.

Purpose of the Study:

  • To review current knowledge on epigenetic reprogramming in pancreatic premalignant initiation and progression.
  • To explore the clinical applications of epigenetic alterations as biomarkers and therapeutic targets for PC.

Main Methods:

  • This review summarizes existing literature on epigenetic mechanisms in pancreatic premalignancy.
  • Focuses on chromatin remodeling, histone, DNA, and RNA modifications, non-coding RNA, and alternative splicing.
  • Examines how these alterations impact gene expression and chromatin structure.

Main Results:

  • Epigenetic modifications alter chromatin structure and gene accessibility, silencing tumor suppressors or activating oncogenes.
  • Expression profiles of epigenetic molecules show promise for PC biomarker development.
  • Further investigation is needed on how epigenetic machinery regulates reprogramming in premalignant lesions.

Conclusions:

  • Epigenetic reprogramming is crucial in pancreatic premalignant lesion development and PC progression.
  • Epigenetic biomarkers offer potential for early PC detection and diagnosis.
  • Targeted epigenetic therapies represent a promising strategy for PC treatment.