Experimental and clinical data indicating the psychotropic properties of progestogens

Investigations of the psychotropic effects of progestogens employing the technique of quantitative pharmaco-EEG indicated that progestogens produce a profile similar to that of the minor tranquillizers. Healthy volunteers received single oral doses in a double-blind controlled study. A short review of the clinical literature adds support to the suggestion that progestogens have sedative properties.