Is Triglyceride-Glucose Index a Valuable Parameter in Peripheral Artery Disease?

Area of Science:

• Cardiovascular Medicine
• Metabolic Syndrome Research
• Diagnostic Biomarkers

Background:

• Peripheral artery disease (PAD) is a growing public health concern associated with significant morbidity.
• The triglyceride-glucose (TyG) index, a marker of insulin resistance, has emerged as a potential indicator for various cardiovascular conditions.
• Understanding novel predictors for PAD is crucial for early detection and intervention.

Purpose of the Study:

• To investigate the association between the triglyceride-glucose (TyG) index and the presence of peripheral artery disease (PAD).
• To identify independent predictors of PAD, including the TyG index, through multivariate analysis.

Main Methods:

• A single-center, observational, retrospective study involving 440 participants (211 with PAD, 229 controls).
• Color Doppler ultrasonography was used for patient evaluation.
• Statistical analyses included multivariate regression to determine independent predictors and receiver operating characteristic (ROC) curve analysis for cut-off value determination.

Main Results:

• Patients with PAD exhibited significantly higher TyG index levels compared to healthy controls (9.19 ± 0.57 vs. 8.80 ± 0.59; p < 0.001).
• The TyG index was identified as an independent predictor of PAD (odds ratio = 1.111, p < 0.001).
• Other independent predictors included age, male gender, diabetes mellitus, hypertension, coronary artery disease, white blood cell count, and creatinine.

Conclusions:

• Elevated TyG index values serve as an independent predictor for peripheral artery disease.
• The TyG index, with a determined cut-off value of 9.06, demonstrates potential utility in identifying individuals at risk for PAD.
• These findings suggest that the TyG index could be a valuable tool in the early assessment and management of PAD.