Successful treatment of granulomatosis with polyangiitis using tocilizumab combined with glucocorticoids: A case
Peng-Fang Tang1, Long-Chuan Xu2, Wen-Ting Hong1
1Department of Rheumatology, Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.
Background:
Tocilizumab is a humanized monoclonal antibody against the interleukin-6 (IL-6) receptor that is commonly used to treat large vessel vasculitis and antineutrophil cytoplasmic antibody-related small vessel vasculitis. However, tocilizumab in combination with glucocorticoids for successfully treating granulomatosis with polyangiitis (GPA) has rarely been reported.
Case Summary:
Here, we report a 40-year-old male patient who suffered GPA for 4 years. He was treated with multiple rounds of drugs, including cyclophosphamide, Tripterygium wilfordii, mycophenolate mofetil, and belimumab, with no improvement. In addition, he exhibited persistently high IL-6 levels. After tocilizumab treatment, his symptoms improved, and his inflammatory marker levels returned to normal.
Conclusion:
Tocilizumab may be effective for treating GPA.
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