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Surgical microscope integrated MHz SS-OCT with live volumetric visualization.

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We developed a flexible MHz swept-source optical coherence tomography (SS-OCT) system for ophthalmic surgery. This advanced imaging tool offers high speed and multiple modes, enhancing surgical visualization beyond current limitations.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Intraoperative optical coherence tomography (OCT) offers clinical benefits but is limited by current spectral-domain OCT systems' inflexibility, slow speed, and shallow imaging depth.
  • These limitations hinder the widespread adoption of OCT in routine ophthalmic surgery.

Purpose of the Study:

  • To present a highly flexible swept-source OCT (SS-OCT) engine integrated with an ophthalmic surgical microscope.
  • To achieve MHz A-scan rates for enhanced intraoperative imaging capabilities.

Main Methods:

  • Development of an SS-OCT engine utilizing a MEMS tunable VCSEL for adaptable imaging modes.
  • Implementation of a reconstruction and rendering platform for real-time 4D-OCT visualization.
  • Evaluation of imaging modes in mock surgical procedures using ex vivo bovine and porcine eyes.

Main Results:

  • Demonstration of the most flexible SS-OCT engine operating at MHz A-scan rates for ophthalmic surgery.
  • Successful implementation of application-specific imaging modes including diagnostic, documentary, live B-scan, and 4D-OCT rendering.
  • Validation of the system's performance in simulated surgical scenarios.

Conclusions:

  • The developed MHz SS-OCT system provides a flexible and high-speed solution for intraoperative visualization in ophthalmic surgery.
  • This technology has the potential to overcome the limitations of current OCT systems, improving surgical guidance and outcomes.
  • Further investigation into the applicability and limitations in real surgical settings is warranted.