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Malignant pleural effusion diagnosis and therapy

Liangliang Yang1, Yue Wang1

  • 1Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Erdao District, Changchun 130033, China.

Open Life Sciences
|March 6, 2023
PubMed

Insights

Malignant pleural effusion (MPE) is a serious complication of advanced cancer. This review covers MPE development, diagnosis, and treatment, offering clinicians the latest evidence for individualized patient care.

Area of Science:

  • Oncology
  • Pulmonology
  • Pathophysiology

Background:

  • Malignant pleural effusion (MPE) is a significant complication in advanced cancers, associated with high morbidity and mortality.
  • MPE substantially impacts patient quality of life and survival.
  • Current understanding of MPE development mechanisms remains incomplete, posing diagnostic and therapeutic challenges.

Purpose of the Study:

  • To review recent research advances in the mechanisms of malignant pleural effusion development.
  • To provide an overview of current diagnostic strategies for MPE.
  • To summarize contemporary treatment approaches for MPE.

Main Methods:

  • Comprehensive literature search of research on MPE mechanisms, diagnosis, and treatment.
  • Synthesis of evidence from preclinical and clinical studies.
  • Review of recent advancements and clinical guidelines.

Main Results:

  • Advances in understanding MPE pathogenesis, including cellular and molecular pathways.
  • Improved diagnostic tools and biomarkers for MPE detection.
  • Evolving treatment strategies focusing on symptom management and targeted therapies.

Conclusions:

  • Individualized treatment plans are crucial for managing MPE, considering patient wishes, health status, and prognosis.
  • Further research is needed to fully elucidate MPE mechanisms and develop more effective therapies.
  • A multidisciplinary approach is essential for optimizing comprehensive care for patients with MPE.
Keywords:
diagnosismalignant pleural effusionmechanismtherapytreatment

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