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Real-World Prescribing Patterns for Hypertensive Children in China from 2018 to 2021: A Cross-Sectional Multicenter

Qin Qian1, Yu-Zhen Wang1, Lian-Di Kan1

  • 1Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, People's Republic of China.

Risk Management and Healthcare Policy
|March 6, 2023
PubMed

Insights

Pediatric hypertension is a growing concern, but antihypertensive drug use in children is not well understood. This study reveals that current medication practices in China often deviate from established guidelines, raising questions about rational drug use.

Area of Science:

  • Cardiology
  • Pediatrics
  • Pharmacology

Background:

  • Pediatric hypertension serves as an early indicator of adult cardiovascular diseases.
  • Understanding antihypertensive drug utilization patterns in children is crucial but often overlooked.

Purpose of the Study:

  • To investigate the epidemiological characteristics of pediatric hypertension in China.
  • To analyze real-world antihypertensive drug use patterns in pediatric patients.

Main Methods:

  • Analysis of demographic, diagnosis, and medication prescription data.
  • Evaluation of antihypertensive drug types, comorbidities, and adherence to Chinese hypertension guidelines.

Main Results:

  • 1301 prescriptions involving 1880 antihypertensive orders were analyzed.
  • Calcium channel blockers (CCB), angiotensin II receptor blockers (ARB), and beta-blockers (BB) were most common; kidney diseases were frequent comorbidities.
  • Only 14.20% of prescribed drugs and 84.93% of combinations aligned with guidelines, indicating suboptimal adherence.

Conclusions:

  • This study provides novel insights into pediatric hypertension and drug use in China.
  • Findings highlight significant deviations from hypertension management guidelines in pediatric care.
  • Concerns regarding the rational use of antihypertensives in children warrant further investigation and improved clinical practice.
Abstract

Keywords:
antihypertensive drugsdrug combinationhypertensive childrenprescription

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