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Updated: Aug 8, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Probiotics intervention in preventing conversion of impaired glucose tolerance to diabetes: The PPDP follow-on study
Qun Yan1, Weiting Hu2, Yan Tian1
1Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Objectives:
The purpose of this study was to assess the incidence of type 2 diabetes mellitus (T2DM) after 6 years in patients with IGT who received early probiotic intervention in the Probiotics Prevention Diabetes Program (PPDP) trial.
Methods:
77 patients with IGT in the PPDP trial were randomized to either probiotic or placebo. After the completion of the trial, 39 non-T2DM patients were invited to follow up glucose metabolism after the next 4 years. The incidence of T2DM in each group was assessed using Kaplan-Meier analysis. The 16S rDNA sequencing technology was used to analyze gut microbiota's structural composition and abundance changes between the groups.
Results:
The cumulative incidence of T2DM was 59.1% with probiotic treatment versus 54.5% with placebo within 6 years, there was no significant difference in the risk of developing T2DM between the two groups (P=0.674).
Conclusions:
Supplemental probiotic therapy does not reduce the risk of IGT conversion to T2DM.
Clinical Trial Registration:
https://www.chictr.org.cn/showproj.aspx?proj=5543, identifier ChiCTR-TRC-13004024.
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