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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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Emerging role of miRNAs in the regulation of ferroptosis

Reza Mahmoudi-Lamouki1, Sepideh Kadkhoda2, Bashdar Mahmud Hussen3

  • 1Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Molecular Biosciences
|March 6, 2023
PubMed

Insights

MicroRNAs regulate ferroptosis, a unique cell death pathway crucial in diseases. This review details microRNA involvement in ferroptosis mechanisms and various non-malignant and malignant disorders.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathology

Background:

  • Ferroptosis is a distinct iron-dependent cell death characterized by lipid ROS accumulation, mitochondrial shrinkage, and cristae reduction.
  • Ferroptosis plays a significant role in the pathogenesis of numerous diseases, making it a key therapeutic target.
  • Emerging research highlights the regulatory role of microRNAs in the ferroptosis pathway.

Purpose of the Study:

  • To review the current understanding of microRNA involvement in ferroptosis.
  • To explore the impact of microRNAs on ferroptosis mechanisms and disease pathology.
  • To summarize the role of specific microRNAs (miR-675, miR-93, miR-27a, miR-34a, miR-141) in ferroptosis.

Main Methods:

  • Literature review of recent studies on microRNAs and ferroptosis.
  • Analysis of microRNA regulation of iron, antioxidant, and lipid metabolism in ferroptosis.
  • Synthesis of findings related to microRNA-mediated ferroptosis in various diseases.

Main Results:

  • MicroRNAs significantly impact ferroptosis by modulating iron, antioxidant, and lipid metabolism.
  • Specific microRNAs (e.g., miR-675, miR-93) have been identified as key regulators of ferroptosis.
  • MicroRNA dysregulation is implicated in the pathology of diverse conditions including cancers, cardiovascular diseases, and neurological disorders.

Conclusions:

  • MicroRNAs are critical regulators of ferroptosis, influencing its core mechanisms.
  • Understanding microRNA-ferroptosis interactions offers potential therapeutic strategies for ferroptosis-associated diseases.
  • This review consolidates knowledge on microRNAs in ferroptosis for both malignant and non-malignant disorders.
Keywords:
cancerexpressionferroptosismiRNApathwa

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