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Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Gastritis-I: Introduction and Types01:27

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Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
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Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
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Other Disorders of Digestive System01:30

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Stomach Histology01:26

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The stomach comprises several layers that work together to facilitate digestion and protect the organ. The outermost layer is called the serosa, which provides support and protection to the stomach. The muscularis externa layer is responsible for the mechanical breakdown of food by contracting and moving the stomach. The submucosa layer, located beneath the muscularis externa, contains connective tissue, blood vessels, nerves, and glands that secrete mucus and other substances essential for...
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The human stomach is a vital part of the digestive system, performing multiple functions. It is located within the peritoneum, a serous membrane that lines the abdominal cavity. The stomach plays a central role in processing food substances and interacts with other digestive organs through coordinated digestive processes. The stomach has a characteristic J-shape and is divided into four main regions. The cardia is the first section where the esophagus connects to the stomach and is the entry...
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Related Experiment Video

Updated: Aug 8, 2025

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
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Ischemic gastropathy with "leopard skin" stomach.

Dhairya Gor1, Kyle Wiseman1, Rajvi Gor2

  • 1Department of Internal Medicine, Jersey Shore Medical Center, Neptune, New Jersey.

Proceedings (Baylor University. Medical Center)
|March 6, 2023
PubMed
Summary

Ischemic gastropathy, a rare condition, presents with shock and bleeding. Early endoscopic recognition of its characteristic "leopard skin" appearance is crucial for diagnosis and management.

Keywords:
Ischemic gastropathyleopard skin stomach

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pathophysiology

Background:

  • Ischemic gastropathy is an uncommon gastrointestinal disorder with a high mortality rate.
  • It often manifests with symptoms of shock, gastrointestinal hemorrhage, and anemia.
  • Risk factors include conditions leading to reduced splanchnic blood flow.

Observation:

  • A patient with alcoholic cirrhosis presented with hemorrhagic shock after a fall.
  • Initial upper endoscopy showed active bleeding.
  • A subsequent endoscopy revealed the characteristic "leopard skin" pattern in the gastric mucosa.

Findings:

  • The patient received supportive care but ultimately did not survive.
  • The case highlights the diagnostic challenges and poor prognosis associated with ischemic gastropathy.
  • Delayed endoscopic findings, such as the "leopard skin" appearance, are key diagnostic indicators.

Implications:

  • Prompt diagnosis and treatment are essential for improving outcomes in ischemic gastropathy.
  • Clinicians should maintain a high index of suspicion in patients with risk factors presenting with shock and GI bleeding.
  • Increased awareness of this condition and its endoscopic signs can aid in timely intervention.