Related Experiment Video

Updated: Aug 8, 2025

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

19.6K

Congenital cytomegalovirus infection ‒ a problem of past, present and future

Ingrid Brucknerova, Dusan Dobos, Michal Dubovicky

    Bratislavske Lekarske Listy
    |March 6, 2023
    PubMed

    Insights

    Congenital cytomegalovirus (CMV) infection in newborns can present with varied prenatal and postnatal findings, including brain calcifications and neurological changes. Early detection and intervention are crucial for managing affected infants and preventing long-term complications.

    Area of Science:

    • Neonatal Medicine
    • Infectious Diseases
    • Pediatrics

    Background:

    • Congenital cytomegalovirus (CMV) infection is a significant cause of neonatal morbidity.
    • Understanding the spectrum of clinical manifestations and diagnostic findings is essential for timely management.

    Purpose of the Study:

    • To analyze the prenatal and postnatal characteristics of newborns with congenital CMV infection.
    • To review clinical and laboratory findings, and investigation results in affected neonates.

    Main Methods:

    • Retrospective analysis of 11 newborns diagnosed with congenital CMV infection.
    • Inclusion criteria: hospitalization at the Neonatal Department of Intensive Medicine between January 1st, 2012, and March 31st, 2022.

    Main Results:

    • Prenatal sonography identified brain calcifications and ventriculomegaly in several cases.
    • Neurological examinations revealed varying degrees of muscular tonicity and spontaneous activity changes.
    • Auditory and ophthalmological assessments indicated abnormalities such as unilateral positive otoacoustic emissions and chorioretinitis.

    Conclusions:

    • Findings highlight the diverse clinical presentations of congenital CMV infection in neonates.
    • Public health strategies, including population education and infection monitoring, are vital for prevention.
    • Early detection and appropriate treatment, including antiviral therapy, are critical for improving outcomes.
    Abstract

    Keywords:
    cytomegalovirusnewborntherapy complications.

    More Related Videos

    Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates05:53

    Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

    Published on: July 6, 2013

    15.1K
    qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue08:08

    qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

    Published on: July 9, 2014

    15.8K

    Related Concept Videos

    Immunodeficiency Diseases01:25

    Immunodeficiency Diseases

    Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
    There are three main causes of immunodeficiency...
    1.1K
    Cystic Fibrosis: Pathogenesis01:23

    Cystic Fibrosis: Pathogenesis

    Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
    CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
    320
    Sexually Transmitted Infections01:26

    Sexually Transmitted Infections

    Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
    384
    Immunological Memory01:23

    Immunological Memory

    Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
    What is Immunological Memory?
    Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
    2.0K
    Microorganisms in Medicine and Therapeutics01:29

    Microorganisms in Medicine and Therapeutics

    Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
    100
    Teratogenicity01:07

    Teratogenicity

    The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
    2.6K