Related Experiment Video
Updated: Aug 8, 2025
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Serum vitamin D levels and inflammatory status in COVID-19 patients
Insights
This study found that severe COVID-19 patients have lower vitamin D levels and higher inflammatory markers compared to moderate cases. These findings highlight the link between vitamin D status, inflammation, and COVID-19 severity.
Area of Science:
- Clinical Medicine
- Immunology
- Nutritional Science
Background:
- COVID-19 presents with diverse clinical features and laboratory findings influenced by disease severity.
- Inflammatory responses play a critical role in COVID-19 pathogenesis.
Purpose of the Study:
- To investigate the correlation between serum vitamin D levels and key inflammatory markers in hospitalized COVID-19 patients.
- To assess how these parameters differ based on the severity of COVID-19.
Main Methods:
- A cohort of 100 hospitalized COVID-19 patients (55 moderate, 45 severe) was analyzed.
- Laboratory tests included complete blood count, biochemical parameters, C-reactive protein, procalcitonin, ferritin, interleukin-6, and 25-OH vitamin D.
Main Results:
- Severe COVID-19 patients exhibited significantly lower serum vitamin D levels (16.54±6.51 ng/ml) compared to moderate cases (20.37±5.63 ng/ml).
- Elevated levels of interleukin-6, C-reactive protein, ferritin, and LDH were observed in patients with severe disease.
Conclusions:
- A significant relationship exists between increased inflammatory laboratory markers, diminished vitamin D levels, and greater COVID-19 disease severity.
- Vitamin D status may serve as an indicator of the inflammatory state in COVID-19 patients.
Objectives:
The coronavirus 2019 disease (COVID-19) is characterized by a heterogeneous clinical presentation, a complex pathophysiology and a wide range of laboratory findings, depending on disease severity.
Background:
We studied some laboratory parameters in correlation with vitamin D status representing the inflammatory state in hospitalized COVID-19 patients on admission.
Methods:
The study included 100 COVID-19 patients with moderate (n=55) and severe (n=45) form of the disease. Complete blood count and differential blood count, routine biochemical parameters, C-reactive protein and serum procalcitonin, ferritin, human IL-6 and serum vitamin D (measured as 25-OH vitamin D) concentrations, were performed.
Results:
According to the severity of the disease, patients with severe form had significantly lower serum vitamin D (16.54±6.51 ng/ml vs 20.37±5.63 ng/ml, p=0.0012), higher serum interleukin-6 (41.24±28.46 pg/ml vs. 24.75±16.28 pg/ml, p=0.0003), C-reactive protein (101.49± 57.15 mg/l vs 74.43±42.99 mg/l, p=0.0044), ferritin (969.89±338.37 ng/ml vs 845.96±359.91 ng/ml, p=0.0423) and LDH (1050.53±369.11 U/l vs 905.31±335.57 U/l, p=0.0222) compared to those with moderate form of the disease.
Conclusion:
The presented data provide a relationship between increased inflammatory laboratory markers, low vitamin D levels and disease severity in COVID-19 patients (Tab. 2, Fig. 3, Ref. 32).
More Related Videos
06:29Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
Published on: May 25, 2022
06:03Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
Published on: September 20, 2024
Related Concept Videos
01:22Connective Tissue Cell Types
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
01:23Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:25Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:14Myocarditis III: Medical Management