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Serum NT-ProBNP potential marker of cirrhotic cardiomyopathy

Maya Risteska1, Ludmila Vladimirova-Kitova2, Vladimir Andonov2

  • 1St George University Hospital, Plovdiv, Bulgaria.

Folia Medica
|March 6, 2023
PubMed

Insights

Cirrhotic cardiomyopathy, a cardiac dysfunction in liver cirrhosis, presents with impaired contractility and electrical abnormalities. Elevated brain natriuretic peptide (BNP) and N-terminal pro B-type natriuretic peptide (NT-proBNP) levels indicate cardiac issues in these patients.

Area of Science:

  • Cardiology
  • Hepatology
  • Biochemistry

Background:

  • Liver cirrhosis is frequently linked to cardiac dysfunction.
  • Cirrhotic cardiomyopathy is characterized by systolic and diastolic dysfunction, electrical abnormalities, and chronotropic incompetence.
  • Elevated levels of brain natriuretic peptide (BNP) and N-terminal pro B-type natriuretic peptide (NT-proBNP) are observed in cirrhosis patients with cardiac dysfunction.

Purpose of the Study:

  • To investigate the relationship between liver cirrhosis and cardiac dysfunction.
  • To explore the clinical features of cirrhotic cardiomyopathy.
  • To examine the role of BNP and NT-proBNP as biomarkers in cirrhotic cardiomyopathy.

Main Methods:

  • Review of previous studies on liver cirrhosis and cardiac function.
  • Analysis of clinical features associated with cirrhotic cardiomyopathy.
  • Assessment of BNP and NT-proBNP levels in cirrhosis patients.

Main Results:

  • Cardiac dysfunction is a common complication of liver cirrhosis.
  • Key features include impaired contractility, diastolic dysfunction, and electrical abnormalities.
  • Elevated BNP and NT-proBNP levels correlate with both systolic and diastolic dysfunction.

Conclusions:

  • Cirrhotic cardiomyopathy is a significant clinical entity in liver cirrhosis.
  • BNP and NT-proBNP serve as important indicators of cardiac dysfunction in these patients.
Abstract

Keywords:
cirrhotic cardiomyopathy diastolic dysfunction liver cirrhosis portal hypertension prolonged QTc

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