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Related Experiment Video

Updated: Aug 8, 2025

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

PET in bladder cancer imaging.

Dina Muin¹, Ekaterina Laukhtina^2,3, Marcus Hacker¹

¹Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine.

Current Opinion in Urology

|March 6, 2023

Summary

Positron emission tomography (PET) combined with CT or MRI enhances bladder cancer staging accuracy. Future research with novel tracers like immunoPET may personalize immunotherapy treatment.

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Last Updated: Aug 8, 2025

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

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Published on: July 28, 2012

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

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Published on: March 29, 2019

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Area of Science:

Oncology
Medical Imaging
Nuclear Medicine

Background:

Bladder cancer (BCa) staging is crucial for treatment planning.
Accurate detection of metastases is essential for effective patient management.

Approach:

This review summarizes evidence on PET/CT and PET/MRI for BCa staging.
It discusses radiopharmaceuticals for characterizing tumor biology and guiding treatment.

Key Points:

PET/CT improves nodal metastasis detection over CT alone.
PET/MRI offers potential for early tumor detection due to MRI's soft tissue contrast, but current sensitivity for early-stage BCa is limited by [18F]FDG renal excretion.
ImmunoPET shows promise for identifying PD-L1 positive tumors, aiding immunotherapy selection.

Conclusions:

PET/CT and PET/MRI are valuable tools for BCa staging, outperforming conventional CT in detecting metastases.
Future advancements in PET technology, including novel radiopharmaceuticals and machine learning, will enhance early detection, staging, monitoring, and precision medicine.
ImmunoPET holds significant potential for advancing precision medicine in the era of immunotherapy.