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A sticky carbohydrate meets a mussel adhesive: Catechol-conjugated levan for hemostatic and wound healing
Asila Osman1, Enhui Lin2, Dong Soo Hwang3
1Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, South Korea; Department of Chemical Engineering, University of Khartoum, Khartoum 11115, Sudan.
Abstract:
The stickiest natural polysaccharide, levan, plays a role in metalloproteinase activation, which is an important step involved in the healing of injured tissue. However, levan is easily diluted, washed away, and loses adhesion in wet environments, which limits its biomedical applications. Herein, we demonstrate a strategy for fabricating a levan-based adhesive hydrogel for hemostatic and wound healing applications by conjugating catechol to levan. Prepared hydrogels exhibit significantly improved water solubilities, and adhesion strengths to hydrated porcine skin of up to 42.17 ± 0.24 kPa which is more than three-times that of fibrin glue adhesive. The hydrogels also promote rapid blood clotting and significantly faster healing of rat-skin incisions compared to nontreated samples. In addition, levan-catechol exhibited an immune response close to that of the negative control, which is ascribable to its significantly lower endotoxin level compared to native levan. Overall, levan-catechol hydrogels are promising materials for hemostatic and wound healing applications.
