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Haemodialysis without heparin.

H F Woods, M J Weston, S Bunting

    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
    |January 1, 1978
    PubMed
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    Prostacyclin effectively prevents blood clotting and platelet activation during dialysis. This allows for dialysis without heparin, improving safety and preventing complications like microembolisation and thrombocytopenia.

    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Science
    • Hematology

    Background:

    • Dialysis membranes can activate platelets, leading to thrombus formation, microembolisation, and thrombocytopenia, even with heparin use.
    • Artificial surfaces in extracorporeal circuits pose risks for blood compatibility.

    Purpose of the Study:

    • To evaluate the impact of prostacyclin on platelet activation and thrombus formation during dialysis.
    • To determine if prostacyclin can enable heparin-free dialysis.

    Main Methods:

    • Three groups of greyhounds underwent dialysis: heparin only, heparin plus prostacyclin, and prostacyclin alone.
    • Assessment of microembolisation, thrombus formation, and haemostasis tests were performed.

    Main Results:

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    • Prostacyclin, alone or with heparin, completely eliminated microembolisation from the dialyser.
    • Prostacyclin prevented thrombocytopenia in all treated groups.
    • Heparin-free dialysis was feasible with prostacyclin, showing no extracorporeal circuit clotting or haemostasis changes.

    Conclusions:

    • Prostacyclin is a potent agent for improving blood compatibility during dialysis.
    • Prostacyclin offers a safe alternative to heparin, preventing common dialysis-induced complications.