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Updated: Aug 8, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

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Non-hippo kinases: indispensable roles in YAP/TAZ signaling and implications in cancer therapy

Jun Zhu1, Tiantian Wu1, Qiong Lin2

  • 1School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, China.

Molecular Biology Reports
|March 6, 2023
PubMed

Insights

Yes-associated protein (YAP) and PDZ-binding domain (TAZ) signaling is regulated by non-Hippo kinases, impacting cell growth and cancer. Targeting these pathways offers potential for novel cancer therapies.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • Yes-associated protein (YAP) and PDZ-binding domain (TAZ) are key downstream effectors of the Hippo kinase pathway.
  • YAP/TAZ are crucial for cellular growth, differentiation, tissue development, and are implicated in carcinogenesis.

Purpose of the Study:

  • To review the regulation of YAP/TAZ signaling by non-Hippo kinases.
  • To discuss the therapeutic potential of targeting non-Hippo kinase-regulated YAP/TAZ signaling in cancer.

Main Methods:

  • Literature review of recent studies on YAP/TAZ signaling.
  • Analysis of non-Hippo kinase involvement in YAP/TAZ pathways.

Main Results:

  • Multiple non-Hippo kinases modulate YAP/TAZ signaling beyond the canonical Hippo cascade.
  • This regulation significantly influences cellular functions, especially tumorigenesis and cancer progression.

Conclusions:

  • Non-Hippo kinases represent critical regulators of YAP/TAZ signaling.
  • Targeting these non-Hippo kinase-YAP/TAZ interactions presents a promising avenue for developing new cancer therapies.
Keywords:
Cancer therapyKinase inhibitorsNon-hippo kinasesYAP/TAZ

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