Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Maximum oxygen uptake and cardiac size and function in twins.

R Fagard1, C Van Den Broeke, E Bielen

  • 1Department of Pathophysiology, University of Leuven, Belgium.

The American Journal of Cardiology
|December 1, 1987
PubMed
Summary

Heredity influences aerobic power, but not directly through heart size or function. Cardiac factors are not key in inheriting aerobic capacity, suggesting athletic heart changes are training-induced.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Occurrence of Malnutrition and Associated Factors in Community-Dwelling Older Adults: Those with a Recent Diagnosis of Cancer Are at Higher Risk.

The journal of nutrition, health & aging·2018
Same author

Drievoudige Antihypertensive Behandeling.

Acta clinica Belgica·2016
Same author

The IE180 protein of pseudorabies virus suppresses phosphorylation of translation initiation factor eIF2α.

Journal of virology·2012
Same author

Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase.

Virus research·2010
Same author

Feasibility of Adequate Thrombolytic Therapy with Streptokinase in Peripheral Arterial Occlusions: II. Changes in Peripheral Blood and Thrombolysis in vivo.

British medical journal·2010
Same author

Type 2 diabetes in primary care in belgium: need for structured shared care.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2009

Area of Science:

  • Exercise Physiology
  • Human Genetics
  • Cardiovascular Physiology

Background:

  • Aerobic power, or maximum oxygen uptake, exhibits significant interindividual variability.
  • Understanding the genetic contribution to aerobic power is crucial for distinguishing training effects from inherent capabilities.
  • The role of cardiac structure and function in the heritability of aerobic fitness remains incompletely understood.

Purpose of the Study:

  • To investigate the genetic contribution to maximum oxygen uptake (aerobic power) in healthy young men.
  • To determine if cardiac size and function are significant factors in the inheritance of aerobic power.
  • To evaluate the interplay between genetic predisposition, body composition, and aerobic capacity.

Main Methods:

  • Studied 12 pairs of monozygotic and 12 pairs of dizygotic male twins (ages 18-31).

Related Experiment Videos

  • Assessed maximum oxygen uptake during peak exercise on a bicycle ergometer.
  • Utilized echocardiography to measure cardiac dimensions (left ventricular internal diameter, fractional shortening) and calculated left ventricular mass.
  • Measured body weight, relative weight (Quetelet index), skinfold thickness, resting heart rate, and systolic blood pressure.

    • Main Results:

    • Genetically determined factors included body weight, relative weight, skinfold thickness, resting heart rate, and systolic blood pressure.
    • Significant genetic variation was found for both absolute and weight-adjusted maximum oxygen uptake.
    • Inheritance of aerobic power was not significantly linked to genetic effects on left ventricular internal diameter or fractional shortening.
    • Left ventricular mass showed significant genetic variation, but this was attributable to the inheritance of body size.

    Conclusions:

    • Cardiac factors do not play a significant role in the inheritance of aerobic power.
    • The heritability of aerobic capacity is primarily influenced by non-cardiac factors.
    • Cardiac hypertrophy observed in athletes is likely an adaptation secondary to intensive training, not a direct genetic trait for enhanced aerobic power.