Related Experiment Video
Updated: Aug 8, 2025
Influenza A Virus Studies in a Mouse Model of Infection
Published on: September 7, 2017
Experimental Infection of North American Deer Mice with Clade I and II Monkeypox Virus Isolates
Abstract:
The global spread of monkeypox virus has raised concerns over the establishment of novel enzootic reservoirs in expanded geographic regions. We demonstrate that although deer mice are permissive to experimental infection with clade I and II monkeypox viruses, the infection is short-lived and has limited capability for active transmission.
Insights
Deer mice can be infected with monkeypox virus (MPXV) but do not appear to sustain the virus, limiting potential new reservoirs. This research investigates MPXV transmission dynamics in a potential rodent host.
Area of Science:
- Virology
- Zoonotic Diseases
- Ecology
Background:
- Global spread of monkeypox virus (MPXV) raises concerns about new enzootic reservoirs.
- Understanding potential wildlife hosts is crucial for MPXV transmission dynamics.
Purpose of the Study:
- To assess the susceptibility and transmission capability of deer mice to MPXV.
- To evaluate the potential for deer mice to establish novel enzootic reservoirs.
Main Methods:
- Experimental infection of deer mice with MPXV (clade I and II).
- Monitoring viral load and clinical signs.
- Assessing transmission potential between infected and naive deer mice.
Main Results:
- Deer mice are permissive to experimental MPXV infection.
- Infection in deer mice is short-lived.
- Limited active transmission observed from infected deer mice.
Conclusions:
- Deer mice are unlikely to establish self-sustaining MPXV enzootic reservoirs.
- Further research needed to identify competent reservoirs for MPXV.
