Ultra-low dose computed tomography protocols using spectral shaping for lung cancer screening: Comparison with...

To compare Low-Dose Computed Tomography (LDCT) with four different Ultra-Low-Dose Computed Tomography (ULDCT) protocols for PN classification according to the Lung Reporting and Data System (LungRADS).

Three hundred sixty-one participants of an ongoing lung cancer screening (LCS) underwent single-breath-hold double chest Computed Tomography (CT), including LDCT (120kVp, 25mAs; CTDIvol 1,62 mGy) and one ULDCT among: fully automated exposure control ("ULDCT₁"); fixed tube-voltage and current according to patient size ("ULDCT₂"); hybrid approach with fixed tube-voltage ("ULDCT₃") and tube current automated exposure control ("ULDCT₄"). Two radiologists (R1, R2) assessed LungRADS 2022 categories on LDCT, and then after 2 weeks on ULDCT using two different kernels (R1: Qr49_{ADMIRE 4}; R2: Br49_{ADMIRE 3}). Intra-subject agreement for LungRADS categories between LDCT and ULDCT was measured by the k-Cohen Index with Fleiss-Cohen weights.

LDCT-dominant PNs were detected in ULDCT in 87 % of cases on Qr49_{ADMIRE 4} and 88 % on Br49_{ADMIRE 3}. The intra-subject agreement was: κULDCT₁ = 0.89 [95 %CI 0.82-0.96]; κULDCT₂ = 0.90 [0.81-0.98]; κULDCT₃ = 0.91 [0.84-0.99]; κULDCT₄ = 0.88 [0.78-0.97] on Qr49_{ADMIRE 4}, and κULDCT₁ = 0.88 [0.80-0.95]; κULDCT₂ = 0.91 [0.86-0.96]; κULDCT₃ = 0.87 [0.78-0.95]; and κULDCT₄ = 0.88 [0.82-0.94] on Br49_{ADMIRE 3}. LDCT classified as LungRADS 4B were correctly identified as LungRADS 4B at ULDCT₃, with the lowest radiation exposure among the tested protocols (median effective doses were 0.31, 0.36, 0.27 and 0.37 mSv for ULDCT₁, ULDCT₂, ULDCT₃, and ULDCT₄, respectively).

ULDCT by spectral shaping allows the detection and characterization of PNs with an excellent agreement with LDCT and can be proposed as a feasible approach in LCS.