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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Cardiometabolic Risk Factors in Atorvastatin-Treated Women with Euthyroid Autoimmune Thyroiditis

Robert Krysiak1, Karolina Kowalcze2, Bogusław Okopień1

  • 1Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Pharmacology
|March 6, 2023
PubMed

Insights

Women with Hashimoto's thyroiditis may experience less benefit from atorvastatin treatment for cardiometabolic risk factors compared to those without thyroid autoimmunity. Further research is needed to optimize statin therapy in autoimmune thyroid disease.

Area of Science:

  • Endocrinology
  • Cardiology
  • Immunology

Background:

  • Autoimmune thyroiditis is linked to elevated cardiometabolic risk.
  • Statins can reduce thyroid antibody titers.
  • Cardiometabolic risk markers in statin-treated women with thyroid autoimmunity warrant investigation.

Purpose of the Study:

  • To compare plasma markers of cardiometabolic risk in euthyroid women with and without Hashimoto's thyroiditis receiving atorvastatin.
  • To assess the impact of atorvastatin on lipids, glucose homeostasis, and inflammatory markers in these groups.

Main Methods:

  • Matched comparison of euthyroid women with hypercholesterolemia on atorvastatin: 29 with Hashimoto's (Group A) and 29 without thyroid pathology (Group B).
  • Measurement of plasma lipids, glucose homeostasis markers, uric acid, hsCRP, fibrinogen, homocysteine, and 25-hydroxyvitamin D before and after 6 months of treatment.

Main Results:

  • Groups differed at baseline in antibody titers, insulin sensitivity, and several plasma markers.
  • Atorvastatin showed a more pronounced reduction in hsCRP and homocysteine in Group B (no thyroid pathology).
  • Group B experienced decreases in uric acid and fibrinogen, and an increase in 25-hydroxyvitamin D; Group A showed reduced insulin responsiveness.

Conclusions:

  • Euthyroid women with Hashimoto's thyroiditis may derive less benefit from atorvastatin regarding cardiometabolic risk markers compared to women without thyroid pathology.
  • These findings suggest potential differences in atorvastatin efficacy based on thyroid autoimmunity status.
Abstract

Keywords:
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitorsAutoimmune thyroiditisHypercholesterolemiaPleiotropic effectsRisk factors

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