[The regulatory role and related mechanisms of macrophages in wound healing]
1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China.
Abstract:
Wound healing is a complex process under precise regulation, including multiple stages such as inflammation, anti-inflammatory, and regeneration. Macrophages play an important regulatory role in the differentiated process of wound healing due to their obvious plasticity. If macrophages fail to express specific functions in a timely manner, it will affect the healing function of tissues and lead to pathological tissue healing. Therefore, it is of great significance to understand the different functions of different types of macrophages and to regulate them specifically in different stages of wound healing to promote the healing and regeneration of wound tissue. In this paper, we illustrate the different functions of macrophages in the wound and their basic mechanisms, according to the basic process of wound healing, and emphasize the strategies of macrophage regulation that may be applied to clinical treatment in the future.
Insights
Macrophages are key regulators of wound healing. Understanding and targeting macrophage functions at different healing stages can promote tissue regeneration and prevent pathological healing.
Area of Science:
- Immunology
- Regenerative Medicine
- Cell Biology
Context:
- Wound healing is a dynamic biological process involving inflammation, tissue repair, and regeneration.
- Macrophages exhibit remarkable plasticity, adapting their functions to different stages of wound healing.
- Dysfunctional macrophage activity can impede healing, leading to chronic wounds or excessive scarring.
Purpose:
- To elucidate the diverse roles of macrophages throughout the wound healing cascade.
- To explore the underlying mechanisms governing macrophage plasticity in wound environments.
- To highlight potential therapeutic strategies targeting macrophages for enhanced wound repair.
Summary:
- Macrophages are crucial for regulating wound healing stages, including inflammation and regeneration.
- Their plasticity allows them to adopt different functional phenotypes critical for timely tissue repair.
- This review details macrophage functions and mechanisms, emphasizing their importance in promoting wound regeneration.
Impact:
- Provides insights into macrophage-driven wound healing for therapeutic interventions.
- Identifies strategies for modulating macrophage behavior to improve clinical outcomes in wound care.
- Advances understanding of cellular contributions to tissue regeneration and pathological healing processes.
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