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Urinary fibrin degradation products--a three year comparative study.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
|January 1, 1978
Summary
Urinary fibrin degradation products (FDP) can indicate disease activity in glomerulonephritis and urinary tract infections. However, FDP levels are not always reliable for diagnosing these conditions or kidney transplant rejection.
Area of Science:
- Nephrology
- Clinical Chemistry
Background:
- Urinary fibrin degradation products (FDP) are markers of fibrinolysis.
- Their diagnostic utility in kidney diseases and post-transplant complications requires further investigation.
Purpose of the Study:
- To evaluate the diagnostic and prognostic value of urinary FDP in chronic proliferative glomerulonephritis (GN), urinary tract infections (UTI), and kidney transplant recipients.
Main Methods:
- Urinary FDP levels were measured using Merskey's passive haemagglutination test.
- Patients included those with biopsy-proven GN, UTI, and kidney transplant recipients.
Main Results:
- Active GN and acute UTI showed significantly higher urinary FDP levels compared to latent GN and chronic UTI, respectively.
- Urinary FDP levels correlated with steroid sensitivity in nephrotic syndrome (NS).
- A rise in urinary FDP post-transplantation indicated acute rejection, but absence did not rule out rejection.
Conclusions:
- Urinary FDP levels show potential for assessing disease activity in GN and UTI, and for predicting prognosis in NS.
- While elevated FDP suggests rejection after kidney transplantation, negative results do not exclude it, limiting diagnostic value.