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Published on: November 15, 2013
Relationship of Sulfatides Physiological Function and Peroxisome Proliferator-Activated Receptor α
Tong-Tong Li1, Gang Li2, Rui Hu3
1General Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
Abstract:
Sulfatides are unique sphingolipids present in the serum and the plasma membrane. Sulfatides exert important functions in a number of systems in the human body, including the nervous, immune, cardiovascular, and coagulation systems.Furthermore, it is closely related to tumor occurrence, development, and metastasis. Peroxisome proliferators-activated receptor α (PPARα) is a class of the nuclear receptor superfamily of transcription factors, which is a potential regulator of sulfatides. This review not only summarizes the current knowledge on the physiological functions of sulfatides in various systems, but also discusses the possible PPARα regulatory mechanisms in sulfatide metabolism and functions. The results of the present analysis provide deep insights and further novel ideas for expanding the research on the physiological function and clinical application of sulfatides.
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