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Related Experiment Video

Updated: Aug 7, 2025

In vitro Functional Characterization of Mouse Colorectal Afferent Endings

In vitro Functional Characterization of Mouse Colorectal Afferent Endings

Published on: January 21, 2015

Defecatory Function Studies Using the Fecobionics Device Are Repeatable.

Kar Man Lo¹, Daming Sun², Ssu-Chi Chen³

¹California Medical Innovations Institute, San Diego, CA, USA.

Digestive Diseases and Sciences

|March 6, 2023

Summary

This summary is machine-generated.

The Fecobionics device shows acceptable repeatability for anorectal function studies. Intra-individual variation was significantly lower than inter-individual variation, indicating reliable data collection for physiological assessments.

Keywords:

Anorectal physiology Defecation Defecatory function Fecobionics Repeatability

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Area of Science:

Gastroenterology
Physiology
Medical Technology

Background:

Limited data exists on the repeatability of anorectal function studies using current technologies.
Fecobionics, a novel multi-sensor simulated feces, integrates data from existing tests.

Purpose of the Study:

To assess the repeatability of anorectal data acquired with the Fecobionics device.
To analyze key pressure and bending parameters for reliability.

Main Methods:

Assessed 260 Fecobionics studies, identifying 19 subjects with repeated measurements.
Analyzed pressure and bending parameters using Bland Altman plots.
Calculated inter- and intra-individual coefficients of variation (CV).

Main Results:

Normal subjects (15) showed bias within confidence intervals for most parameters.
Inter-individual CV for bend angle was 10.1-10.7%; pressure parameters ranged from 16.3-51.6%.
Intra-individual CVs were approximately half of inter-individual CVs (9.7-27.6%).

Conclusions:

Fecobionics demonstrates acceptable repeatability for anorectal function assessment.
Intra-individual variation is substantially lower than inter-individual variation.
Further large-scale studies are needed to explore factors influencing repeatability.