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Updated: Aug 7, 2025
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
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Oncolytic Virus-Driven Biotherapies from Bench to Bedside
Shijie Duan1, Shuhang Wang2, Lei Qiao3
1Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Phase I Clinical Trials Center, The First Hospital of China Medical University, Shenyang, 110001, China.
Small (Weinheim an Der Bergstrasse, Germany)
|March 7, 2023
Summary
Oncolytic virus therapy (OVT) shows promise but struggles in clinical trials. Combination therapies and improved delivery methods are key to enhancing the efficacy of oncolytic viruses (OVs) for cancer treatment.
Area of Science:
- Oncology
- Virology
- Immunotherapy
Background:
- Oncolytic virus (OV) therapy is a rapidly advancing cancer treatment.
- While promising at cellular and organismal levels, clinical trials show limited efficacy for single-agent OVT.
- Challenges include restricted injection sites and poor targeting with intravenous administration.
Purpose of the Study:
- To review the development and antitumor mechanisms of OVs.
- To highlight advances in OVT delivery routes for improved efficacy.
- To discuss OVT monotherapy versus combination therapy in clinical trials.
Main Methods:
- Review of scientific literature on OV development and applications.
- Analysis of clinical trial data for OVT monotherapy and combination strategies.
- Discussion of delivery route advancements for OVs.
Main Results:
- Integrated approaches combining OVT with immunotherapy, chemotherapy, or radiotherapy show considerable efficacy.
- OVT monotherapy faces challenges in clinical efficacy, particularly with delivery methods.
- Optimized OVT delivery is crucial for successful tumor treatment.
Conclusions:
- Combination therapies significantly enhance OVT efficacy compared to monotherapy.
- Improving OV delivery routes is essential for overcoming current clinical limitations.
- Further research should focus on developing safer and more effective OVT strategies.
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