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Updated: Aug 7, 2025

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Direct pulp capping procedures - Evidence and practice.

Rafiqul Islam¹, Md Refat Readul Islam², Toru Tanaka¹

¹Department of Restorative Dentistry, Faculty of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Japan.

The Japanese Dental Science Review

|March 7, 2023

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Direct pulp capping (DPC) aims to heal exposed pulp and form a mineralized barrier using dental biomaterials. Successful DPC promotes pulp healing, avoiding extensive treatments.

Area of Science:

Dentistry
Biomaterials Science
Regenerative Medicine

Background:

Direct pulp capping (DPC) is a dental procedure to preserve pulp vitality.
Successful DPC requires pulp healing and formation of a mineralized tissue barrier to prevent microbial invasion.
Pulp inflammation and infection must be reduced for successful mineralized tissue barrier formation.

Purpose of the Study:

To review direct pulp capping (DPC) procedures and biomaterials.
To explore the mechanisms by which DPC materials promote pulpal healing.
To discuss factors influencing DPC healing, clinical considerations, and future directions.

Main Methods:

Literature review of direct pulp capping (DPC) studies.
Analysis of dental biomaterials used in DPC.

Keywords:

Bioceramics Calcium hydroxide Direct pulp capping Mineral trioxide aggregate Pulp capping materials Vital pulp therapy

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Last Updated: Aug 7, 2025

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

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Published on: January 12, 2017

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Examination of mechanisms promoting mineralized tissue formation and pulp healing.

Main Results:

Exposed pulp tissue exhibits an intrinsic capacity for healing when treated with various dental biomaterials.
Mineralized tissue barrier formation is a key indicator of successful pulp healing after DPC.
Reduction of pulp inflammation and infection is crucial for successful DPC outcomes.

Conclusions:

Direct pulp capping (DPC) is a viable approach to promote pulp healing and barrier formation.
The choice of dental biomaterial and management of pulp inflammation are critical for DPC success.
Further research into DPC materials and clinical considerations can enhance treatment sustainability.