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The Changes in Respiratory and Enteric Adenovirus Epidemiology in Korea From 2017 to June 2022

Kyung-Ran Kim1, Jisu Won2, Hyungjun Kim2

  • 1Department of Pediatrics, Gyeongsang National University Changwon Hospital, Changwon, Korea.

Journal of Korean Medical Science
|March 7, 2023
PubMed

Insights

Severe acute hepatitis in children has been linked to adenovirus, primarily enteric adenovirus. This study summarizes adenovirus epidemiology in Korea over five and a half years, focusing on changes since October 2021.

Area of Science:

  • Pediatric Infectious Diseases
  • Hepatology
  • Virology

Background:

  • Global rise in severe acute hepatitis of unknown origin in children since October 2021.
  • Adenovirus, particularly enteric adenovirus, identified in over 50% of affected pediatric cases worldwide.
  • Urgent need for epidemiological data due to the global health concern.

Purpose of the Study:

  • To summarize changes in adenovirus epidemiology in Korea over the past five years and six months.
  • To provide insights into adenovirus trends relevant to unexplained pediatric hepatitis.
  • To support ongoing surveillance and public health responses.

Main Methods:

  • Nationwide surveillance for acute hepatitis of unknown etiology in pediatric patients initiated in May 2022 in Korea.
  • Analysis of adenovirus detection rates and epidemiological patterns over a defined period.
  • Retrospective review of adenovirus epidemiology data.

Main Results:

  • Adenovirus was detected in a significant proportion of pediatric hepatitis cases.
  • Specific trends in adenovirus circulation and detection were observed over the five-and-a-half-year period.
  • Changes in adenovirus epidemiology may correlate with the emergence of unexplained hepatitis.

Conclusions:

  • Adenovirus surveillance is crucial for understanding pediatric hepatitis of unknown etiology.
  • Epidemiological shifts in adenovirus may provide clues to the causes of severe acute hepatitis in children.
  • Continued monitoring is essential for public health preparedness and response.

Keywords:
Acute Hepatitis of Unknown EtiologyAdenovirusEpidemiologyKoreaPediatrics Patients

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