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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

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Injectable zwitterionic cryogels for accurate and sustained chemoimmunotherapy.

Zhang Jing¹, Lu Jie¹, Qian Sunxiang¹

¹College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, P. R. China. zhangjing@zjut.edu.cn.

Journal of Materials Chemistry. B

|March 7, 2023

Summary

New zwitterionic cryogels (SH cryogels) offer a low-immunogenicity platform for chemoimmunotherapy. This approach effectively inhibits breast cancer tumor growth and supports immune cell activity for enhanced cancer treatment.

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Published on: February 7, 2021

Area of Science:

Biomaterials Science
Cancer Research
Immunology

Background:

Chemoimmunotherapy combines chemotherapy and immunotherapy for cancer treatment.
Drug delivery systems are crucial but can trigger immune reactions.
Developing materials with low immunogenicity is essential for effective *in vivo* therapies.

Purpose of the Study:

To develop a novel zwitterionic cryogel (SH cryogel) with minimal immunogenicity for cancer chemoimmunotherapy.
To evaluate the *in vivo* efficacy of SH cryogels for localized and sustained release of drugs and adjuvants.
To investigate the potential of SH cryogels as a platform for promoting anti-tumor immune responses.

Main Methods:

Synthesis of zwitterionic cryogels (SH cryogels) with a macroporous structure.
Loading of chemotherapeutic drugs and immune adjuvants into the cryogels.
Assessment of cryogel injectability and mechanical properties.
*In vivo* experiments to evaluate tumor growth inhibition and immune cell infiltration in a breast cancer model.

Main Results:

SH cryogels exhibited low immunogenicity, good compressibility, and injectability.
Localized and sustained release of drugs and adjuvants from SH cryogels was achieved.
*In vivo* chemoimmunotherapy using SH cryogels significantly inhibited breast cancer tumor growth.
Macroporous structure facilitated immune cell infiltration and antigen presentation.

Conclusions:

SH cryogels represent a promising biomaterial for chemoimmunotherapy due to their low immunogenicity and controlled release capabilities.
The macroporous architecture of SH cryogels supports immune cell activity, enhancing anti-tumor immune responses.
SH cryogels show potential as versatile platforms for cancer treatment and vaccine development.