Asymmetric sulfonylation with sulfur dioxide surrogates: a new access to enantiomerically enriched sulfones
Jun Zhang1, Peiqi Wang1, Yanzhi Li1
1School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China. jie_wu@fudan.edu.cn.
Abstract:
Enantiomerically enriched sulfones occupy a prominent position in pharmaceutical chemistry and synthetic chemistry. Compared with conventional methods, a direct asymmetric sulfonylation reaction with the fixation of sulfur dioxide represents an attractive strategy for the rapid assembly of chiral sulfones with enantiopurity. In this highlight, we survey recent exciting advances in asymmetric sulfonylation by using sulfur dioxide surrogates, and discuss asymmetric induction modes, reaction mechanisms, substrate scope and opportunities for further studies.
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