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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Related Experiment Video

Updated: Aug 7, 2025

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Targeting VCAM-1: a therapeutic opportunity for vascular damage.

Mayarling F Troncoso1,2, Magda C Díaz-Vesga1,3, Fernanda Sanhueza-Olivares1

  • 1Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Expert Opinion on Therapeutic Targets
|March 7, 2023
PubMed
Summary

Vascular cell adhesion molecule-1 (VCAM-1) shows therapeutic potential beyond its role as a pro-inflammatory marker. Further research into pharmacological tools is needed to explore VCAM-1 targeting for vascular diseases.

Keywords:
VCAM-1cardiovascular diseasesinflammationtherapeutic targetvascular damage

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Area of Science:

  • Vascular Biology
  • Immunology
  • Biochemistry

Background:

  • Vascular cell adhesion molecule-1 (VCAM-1) is a transmembrane sialoglycoprotein.
  • It is found in activated endothelial and vascular smooth muscle cells.
  • VCAM-1 mediates inflammatory cell adhesion and transmigration into damaged tissue.

Purpose of the Study:

  • To explore the potential of VCAM-1 as a therapeutic targeting molecule.
  • To review evidence for VCAM-1 targeting in atherosclerosis, diabetes, hypertension, and ischemia/reperfusion injury.

Main Methods:

  • Literature review of current evidence.
  • Discussion of preclinical research using neutralizing antibodies.

Main Results:

  • Emerging evidence suggests VCAM-1 is a promising therapeutic target for vascular diseases.
  • VCAM-1's role extends beyond being a simple biomarker.

Conclusions:

  • VCAM-1 holds significant therapeutic potential for vascular diseases.
  • Development of pharmacological tools to modulate VCAM-1 activity is crucial for further assessment.