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Implementation challenges and real-world impacts of switching pediatric vaccines: A global systematic literature
Chanthawat Patikorn1,2, Warittakorn Kategeaw1, Johnna Perdrizet3
1Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, UT, USA.
Insights
Switching pediatric vaccines can disrupt immunization programs if not managed carefully. Proper planning, resources, and public engagement are crucial for successful vaccine transitions.
Area of Science:
- Immunology
- Public Health
- Health Policy
Background:
- Pediatric national immunization programs often switch vaccines for societal benefit.
- Poor implementation of vaccine switches can lead to negative health outcomes and system inefficiencies.
Approach:
- A systematic review evaluated 33 studies on pediatric vaccine switch implementation challenges.
- The review synthesized findings into three key themes: vaccine availability, program deployment, and vaccine acceptability.
Key Points:
- Vaccine switches present global health-care challenges, often requiring additional resources.
- Implementation hurdles include ensuring vaccine availability, effective program deployment, and public acceptance.
- The economic and societal impacts of vaccine switches are frequently under-researched.
Conclusions:
- Efficient vaccine switches necessitate comprehensive planning, considering benefits, resources, timing, and partnerships.
- Robust surveillance is vital for evaluating program effectiveness post-switch.
- Addressing implementation challenges proactively minimizes negative impacts on pediatric immunization.
Abstract:
Switching a vaccine for another on a pediatric national immunization program is often done for the betterment of society. However, if poorly implemented, switching vaccines could result in suboptimal transitions with negative effects. A systematic review was conducted to evaluate the existing knowledge from identifiable documents on implementation challenges of pediatric vaccine switches and the real-world impact of those challenges. Thirty-three studies met the inclusion criteria. We synthesized three themes: vaccine availability, vaccination program deployment, and vaccine acceptability. Switching pediatric vaccines can pose unforeseen challenges to health-care systems worldwide and additional resources are often required to overcome those challenges. Yet, the magnitude of the impact, especially economic and societal, was frequently under-researched with variability in reporting. Therefore, an efficient vaccine switch requires a thorough consideration of the added benefits of replacing the existing vaccine, preparation, planning, additional resource allocation, implementation timing, public-private partnerships, outreach campaigns, and surveillance for program evaluation.
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