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Orbital myositis induced by alendronate: A case report
Lucie Lefeuvre1, Anna Caruso2, Emmanuel Biver3
1Department of Neurosciences, Division of Neurology, Geneva University Hospital, Geneva and Faculty of Medicine, Geneva, Switzerland.
European Journal of Neurology
|March 7, 2023
Summary
Alendronate, a bisphosphonate for osteoporosis, can rarely cause orbital myositis. Early diagnosis and treatment of this alendronate side effect are crucial for symptom resolution.
Area of Science:
- Ophthalmology
- Rheumatology
- Pharmacology
Background:
- Bisphosphonates, commonly prescribed for osteoporosis, have known side effects.
- Less common adverse effects, such as orbital inflammation, can occur.
Observation:
- A 66-year-old woman developed painful diplopia and eyelid edema after initiating alendronate for osteoporosis.
- Neurological examination and orbital MRI confirmed right orbital myositis.
Findings:
- The patient's orbital myositis was directly linked to alendronate intake.
- No other causes for the orbital myositis were identified.
- Symptoms resolved after discontinuing alendronate and a short course of prednisone.
Implications:
- This case underscores alendronate as a potential cause of orbital myositis.
- Prompt diagnosis of this treatable side effect is essential for effective management.
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