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Updated: Aug 7, 2025
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Update on Pediatric Acute Kidney Injury
Priyanka Khandelwal1, Nadia McLean2, Shina Menon3
1Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, Academic Block, Ansari Nagar, New Delhi 110029, India.
Pediatric Clinics of North America
|March 7, 2023
Summary
Acute kidney injury (AKI) in children is a serious condition impacting multiple organs. Newer diagnostic tools like urinary biomarkers show promise for earlier and more accurate detection beyond serum creatinine.
Area of Science:
- Pediatric Nephrology
- Critical Care Medicine
- Systemic Disease Research
Background:
- Acute kidney injury (AKI) is prevalent in pediatric populations, contributing to substantial illness and death.
- Recent advancements recognize AKI as a systemic condition affecting vital organs like the heart, lungs, and brain.
- Serum creatinine is the standard diagnostic marker for AKI, despite known limitations.
Purpose of the Study:
- To review the current understanding and diagnostic approaches for pediatric AKI.
- To highlight the limitations of traditional diagnostic methods.
- To explore emerging diagnostic strategies for AKI.
Main Methods:
- Literature review of recent studies on pediatric AKI.
- Analysis of traditional diagnostic markers (serum creatinine).
- Evaluation of novel diagnostic approaches including urinary biomarkers, furosemide stress test, and clinical decision support systems.
Main Results:
- Serum creatinine, while standard, has limitations in AKI diagnosis.
- Urinary biomarkers offer potential for improved accuracy and earlier detection of AKI.
- Furosemide stress test and clinical decision support tools are emerging as valuable aids.
Conclusions:
- Pediatric AKI is a complex systemic disorder requiring advanced diagnostic capabilities.
- Newer diagnostic methods are crucial for timely and accurate identification of AKI in children.
- Integrating novel biomarkers and decision support can enhance AKI management and outcomes.
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