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Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

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Sharp cell-type-identity changes differentiate the retrosplenial cortex from the neocortex.

Kaitlin E Sullivan¹, Larissa Kraus¹, Margarita Kapustina¹

¹Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Boulevard, Vancouver, BC, Canada.

|March 7, 2023

Summary

This summary is machine-generated.

The mammalian brain's neocortical layers are usually similar. However, the retrosplenial cortex (RSC) shows distinct cell types at its border and differs from other neocortical areas.

Keywords:

CP: Neuroscience cell types multiplexed in situ hybridization neocortex retrosplenial cortex single-cell RNA sequencing spatial transcriptomics

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Area of Science:

Neuroscience
Cell Biology
Genomics

Background:

Neocortical laminae are fundamental processing layers in the mammalian brain.
These layers are generally considered stereotyped across short distances, with similar cell types in homologous laminae of adjacent regions.
The retrosplenial cortex (RSC) presents a unique case due to sharp cytoarchitectonic differences at its granular-dysgranular border.

Purpose of the Study:

To investigate the excitatory cell-type landscape of the mouse retrosplenial cortex (RSC).
To spatially map and interpret cell types within the RSC.
To determine if the RSC adheres to the general principle of stereotyped neocortical laminae.

Main Methods:

Utilized a variety of transcriptomics techniques.
Performed spatial mapping of cell types.
Analyzed gene expression patterns.

Main Results:

Discovered sharp changes in gene expression and cell-type composition at the RSC's granular-dysgranular border.
Found that laminae homologous to those in the neocortex are distinct in cell-type composition within the RSC.
Identified intrinsic cell-type specializations within the RSC.

Conclusions:

The RSC deviates from the typical neocortical organization.
Cell-type identities in the RSC vary sharply within the region and compared to other neocortical areas.
The RSC exhibits unique organizational principles regarding cell-type specialization.