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Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

1.0K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
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Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

1.1K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
1.1K
ECG Interpretation of Arrhythmias I: Sinus Arrhythmias01:16

ECG Interpretation of Arrhythmias I: Sinus Arrhythmias

278
Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
278
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers01:22

Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers

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Class I antiarrhythmic drugs are used to treat various types of arrhythmias or irregular heart rhythms. These drugs block the sodium (Na+) channels in the cardiac cells, thereby affecting the movement of electrical impulses across the heart. Class I antiarrhythmic drugs are divided into three subgroups: Class IA, Class IB, and Class IC, each with distinct mechanisms of action and effects on the heart.
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
1.5K
Dysrhythmias I: Introduction01:15

Dysrhythmias I: Introduction

24
Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
24
Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Related Experiment Video

Updated: Aug 7, 2025

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk
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Non-coding RNA and arrhythmias: expression, function, and molecular mechanism.

Yuhong Zeng1,2, Na Wu1,2, Zhihui Zhang3

  • 1Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), NO. 30 Gaotanyan Street, Chongqing 400038, People's Republic of China.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|March 7, 2023
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) play a crucial role in the development of cardiac arrhythmias like atrial fibrillation. Understanding ncRNA mechanisms offers new therapeutic targets for these heart rhythm disorders.

Keywords:
ArrhythmiasCircular RNAsLong non-coding RNAsMicroRNAsNon-coding RNAsSmall non-coding RNAs

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Area of Science:

  • Cardiology
  • Molecular Biology
  • Genetics

Background:

  • Arrhythmias, including atrial fibrillation, cause significant morbidity and mortality.
  • Current treatments for arrhythmias have limited efficacy and potential side effects.
  • The precise pathological mechanisms underlying arrhythmias remain incompletely understood.

Approach:

  • This review provides an overview of non-coding RNAs (ncRNAs) in arrhythmias.
  • It examines the expression, roles, and mechanisms of ncRNAs in arrhythmia development.
  • Focus is placed on atrial fibrillation due to its clinical prevalence.

Key Points:

  • Non-coding RNAs (microRNAs, long non-coding RNAs, circular RNAs) are implicated in various diseases, including arrhythmias.
  • ncRNAs are involved in the pathophysiology and progression of cardiac arrhythmias.
  • Dysregulation of ncRNAs contributes to the development of heart rhythm abnormalities.

Conclusions:

  • ncRNAs represent a promising area for understanding arrhythmia mechanisms.
  • Targeting ncRNAs may lead to novel, mechanism-based therapeutic strategies for arrhythmias.
  • Further research into ncRNAs can improve treatment outcomes for patients with heart rhythm disorders.