Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications
Isa Seida1, Mahmoud Alrais1, Ravend Seida1
1International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Clinical and Experimental Immunology
|March 7, 2023
Summary
Adjuvants in vaccines can trigger autoimmune/inflammatory syndrome (ASIA), a condition defined in 2011. This review examines adjuvant effects, ASIA manifestations, and its link to COVID-19 vaccines.
Area of Science:
- Immunology
- Vaccinology
- Rheumatology
Background:
- Adjuvants enhance vaccine immunogenicity but can cause adverse effects.
- Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) describes these adverse reactions.
- ASIA symptoms were reported before the syndrome's formal definition in 2011.
Conclusions:
- ASIA provides a framework for understanding and managing adjuvant-related autoimmune/inflammatory conditions.
- Further research is needed to critically evaluate vaccine manufacturing and adjuvant safety.
- Early diagnosis and treatment are crucial for managing ASIA.
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