Diffuse Ganglioneuromatosis of the Colon in a Patient with Neurofibromatosis 1

Ganglioneuromas are rare, benign neurogenic tumors characterized by a proliferation of ganglion cells, nerve fibers, and support cells of the nervous system. They have been classified into three groups: solitary, polyposis, and diffuse. The diffuse type has several syndromic associations including multiple endocrine neoplasia syndrome type 2B and, less commonly, neurofibromatosis type 1. We report a case of diffuse ganglioneuromatosis in the colon of a 49-yearold male with a history of neurofibromatosis type 1. Gastrointestinal neoplasms associated with neurofibromatosis type 1 are reviewed.