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Related Experiment Videos

Acoustic reflex dynamics and auditory brain stem responses in multiple sclerosis.

R W Keith1, Y Garza-Holquin, L Smolak

  • 1Department of Otolaryngology, University of Cincinnati Medical Center, OH 45267-0528.

The American Journal of Otology
|September 1, 1987
PubMed
Summary
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This study reveals that acoustic reflex and auditory brain stem responses (ABRs) can detect abnormalities in multiple sclerosis (MS) patients. These electrophysiological tests aid in diagnosing MS even without auditory symptoms.

Area of Science:

  • Neuroscience
  • Audiology
  • Clinical Electrophysiology

Background:

  • Multiple Sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Auditory pathway involvement in MS can occur even in asymptomatic patients.
  • Standard audiological tests may not reveal subtle neurological changes.

Purpose of the Study:

  • To investigate the utility of acoustic reflex dynamics and auditory brain stem responses (ABRs) in diagnosing multiple sclerosis.
  • To determine if these electrophysiological measures can identify abnormalities in MS patients, particularly those without subjective auditory complaints.

Main Methods:

  • Elicited acoustic reflex measures (onset latency, rise time, amplitude) and auditory brain stem responses (ABRs) to clicks.
  • Compared responses between normal subjects and subjects diagnosed with multiple sclerosis.

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  • Analyzed parameters including absolute latencies, interwave latencies, interaural latencies, and response stability.

    • Main Results:

    • Multiple sclerosis subjects demonstrated prolonged acoustic reflex rise times.
    • ABRs in MS subjects showed prolonged absolute latencies, interwave latencies, and interaural latencies.
    • Poor response stability was observed in the ABRs of MS patients.
    • Abnormalities were detected despite the absence of overt auditory symptoms.

    Conclusions:

    • Acoustic reflex dynamics offer diagnostic value beyond traditional threshold and decay measures.
    • Combining comprehensive acoustic reflex testing with ABRs enhances diagnostic capabilities for MS.
    • These electrophysiological assessments are valuable tools for diagnosing MS in patients presenting without auditory symptoms.