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Framework of the Centralized Interactive Phenomics Resource (CIPHER) standard for electronic health data-based

Jacqueline Honerlaw1, Yuk-Lam Ho1, Francesca Fontin1

  • 1Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.

Journal of the American Medical Informatics Association : JAMIA
|March 7, 2023
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Summary

Cataloging electronic health record phenotype algorithm metadata accelerates research. The Department of Veterans Affairs developed the Centralized Interactive Phenomics Resource (CIPHER) standard for metadata collection and reuse across healthcare systems.

Keywords:
algorithmselectronic health recordslibrary collection developmentphenomics

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Area of Science:

  • Biomedical Informatics
  • Clinical Research Informatics
  • Data Science in Healthcare

Background:

  • Developing phenotypes from electronic health records (EHRs) is resource-intensive.
  • Standardized metadata for phenotype algorithms is crucial for accelerating clinical research.
  • Existing phenotype libraries often lack comprehensive metadata regarding algorithm development and validation.

Purpose of the Study:

  • To describe the framework of the Centralized Interactive Phenomics Resource (CIPHER) standard for phenotype metadata collection.
  • To explain the rationale behind the development of the CIPHER standard.
  • To illustrate the application of the CIPHER standard within the Department of Veterans Affairs (VA) healthcare system.

Main Methods:

  • Development of a standardized metadata collection framework for phenotype algorithms.
  • Implementation of the CIPHER standard within the VA phenomics knowledgebase.
  • Capturing algorithm development context, phenotyping methods, and validation approaches.

Main Results:

  • The VA phenomics knowledgebase (CIPHER) currently captures over 5000 phenotypes using the developed standard.
  • The CIPHER standard enhances metadata by including algorithm development context, phenotyping methods, and validation strategies.
  • The standard facilitates the reuse of phenotype algorithms across different healthcare systems.

Conclusions:

  • The CIPHER standard provides a robust framework for collecting and cataloging phenotype algorithm metadata.
  • This standardization accelerates clinical research by enabling efficient reuse of developed phenotypes.
  • The CIPHER standard is applicable beyond the VA, supporting broader healthcare system interoperability.