Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

665
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
665
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

600
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
600

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bacterial-Derived Signals Selectively Remodel Glycosaminoglycan Biosynthetic Pathways in Reconstructed Human Corneal Epithelium.

International journal of molecular sciences·2026
Same author

Contact Lens-Associated Ocular Surface and Corneal Disorders.

Methods and protocols·2026
Same author

Microbial modulation of proteoglycan and glycosaminoglycan biosynthesis in a three-dimensional corneal epithelium model.

Frontiers in cellular and infection microbiology·2026
Same author

Corneal Innervation Research at a Crossroads: A Tool-Driven Roadmap for the Future.

Investigative ophthalmology & visual science·2026
Same author

Novel PPOX Mutation With Ocular Involvement in Variegate Porphyria: Case Report and Literature Review.

Cornea·2026
Same author

Robust registration under large image misalignment using an iterative step-aware transformer with application to corneal confocal microscopy.

Biomedical optics express·2026

Related Experiment Video

Updated: Aug 7, 2025

Investigating Scarless Tissue Regeneration in Embryonic Wounded Chick Corneas
09:31

Investigating Scarless Tissue Regeneration in Embryonic Wounded Chick Corneas

Published on: May 2, 2022

2.0K

Wessely corneal ring phenomenon: An unsolved pathophysiological dilemma.

Raul E Ruiz-Lozano1, Marcelo Salan-Gomez1, Alejandro Rodriguez-Garcia1

  • 1Tecnologico de Monterrey, School of Medicine and Health Sciences, Institute of Ophthalmology and Visual Sciences, Monterrey, Mexico.

Survey of Ophthalmology
|March 7, 2023
PubMed
Summary

Wessely rings, or corneal immune rings, are peripheral cornea infiltrates caused by hypersensitivity reactions. Understanding their immune basis is key to managing these inflammatory conditions.

Keywords:
Complement systemWessely ringscorneal angiogenic privilegecorneal immune ringscorneal infection

More Related Videos

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
07:28

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Published on: July 10, 2018

20.5K
An Epithelial Abrasion Model for Studying Corneal Wound Healing
04:45

An Epithelial Abrasion Model for Studying Corneal Wound Healing

Published on: December 29, 2021

3.3K

Related Experiment Videos

Last Updated: Aug 7, 2025

Investigating Scarless Tissue Regeneration in Embryonic Wounded Chick Corneas
09:31

Investigating Scarless Tissue Regeneration in Embryonic Wounded Chick Corneas

Published on: May 2, 2022

2.0K
Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
07:28

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Published on: July 10, 2018

20.5K
An Epithelial Abrasion Model for Studying Corneal Wound Healing
04:45

An Epithelial Abrasion Model for Studying Corneal Wound Healing

Published on: December 29, 2021

3.3K

Area of Science:

  • Ophthalmology
  • Immunology
  • Corneal Biology

Background:

  • The cornea possesses unique immune privilege due to its avascularity and specific immunological properties.
  • Differences between central and peripheral cornea anatomy and immunology are crucial for maintaining immune privilege.
  • The cornea limits inflammatory cell entry from the conjunctiva, protecting ocular structures.

Purpose of the Study:

  • To elucidate the anatomical and immunological underpinnings of Wessely ring formation.
  • To detail the causes, clinical presentation, and management strategies for corneal immune rings.
  • To explain the role of the complement system (C1) in protecting central corneal transparency.

Main Methods:

  • Review of anatomical and immunological factors contributing to corneal immune privilege.
  • Analysis of hypersensitivity reactions leading to Wessely ring development.
  • Correlation of Wessely rings with infectious and non-infectious etiologies.

Main Results:

  • Wessely rings are peripheral corneal infiltrates resulting from hypersensitivity to foreign antigens.
  • These rings are composed of inflammatory cells and antigen-antibody complexes.
  • Factors like C1 activation in the peripheral cornea contribute to immune privilege and protection of central corneal clarity.

Conclusions:

  • Wessely rings represent a hypersensitivity response within the cornea's immune microenvironment.
  • Understanding the immunological basis aids in diagnosing and managing conditions associated with corneal immune rings.
  • Corneal immune privilege is maintained by anatomical and immunological mechanisms, with peripheral C1 activation playing a protective role.